Cooperativity among afferents for the induction of long-term potentiation in the CA1 region of the hippocampus

摘要: Long-term potentiation of synaptic responses in the hippocampus is a unique form physiological plasticity which can be induced by brief episodes repetitive afferent activity and persist for days or months. The present study describes cooperative (or associative) interactions among afferents to stratum radiatum CA1 induction maintenance this phenomenon. A greater degree long- term was obtained when adjacent were co-actively conditioned, as compared that observed with activation single pathway alone. This cooperativity not result increased postsynaptic discharge during conditioning, shown absence long-term following orthodromic antidromic co-activation pyramidal cells.