The Ability of the Murine Placenta to Absorb Monoclonal Anti-Fetal H-2K antibody from the Maternal Circulation

摘要: In previous work we have found that partially purified 125I-labeled anti H-2 antibody is localized in the placenta when injected i.v. into females pregnant by males bearing target haplotype. This led to concept an antigen-bearing immunoabsorbent barrier between mother and fetus. this report used anti-H-2Kk monoclonal of IgG2a subclass, also labeled with 125I, verify concept, as well improve genetic definition antigen. addition prepared F(ab')2 fragments antibody, these show effect. indicates transport fetally derived tissues via Fc binding not a prerequisite for reaction paternal strain K antigens.