Molecular diagnostics in colorectal carcinoma.

摘要: Molecular pathogenesis and classification of colorectal carcinoma are based on the adenoma-carcinoma sequence in Vogelstein model, serrated polyp pathway, microsatellite instability. The genetic basis for hereditary nonpolyposis cancer is detection mutations. Genetic testing Lynch syndrome includes instability, methylator phenotyping, BRAF mutation, molecular testing. makers include quantitative multigene reverse transcriptase-polymerase chain reaction assay KRAS mutation analysis. Potential biomarkers one-step nucleic acid amplification epigenetic inactivation endothelin 2 3 colon cancer. screening approaches using stool DNA under investigation.