What the physician needs to know about Lynch syndrome: an update.

摘要: The Lynch syndrome (hereditary nonpolyposis colorectal cancer [HNPCC]), is the most common form of hereditary (CRC), accounting for 2% to 7% all CRC cases. next familial adenomatous polyposis (FAP), which accounts less than 1% CRC. crucial clinical importance due fact that it predicts lifetime risk and a litany extra-CRC cancers (of endometrium, ovary, stomach, small bowel, hepatobiliary tract, upper uroepithelial brain) through assessment well-orchestrated family history. A diagnosis almost certain when mutation in mismatch repair gene—most commonly MSH2, MLH1, or, lesser degree, MSH6—is identified. Once diagnosed, potential significant reduction cancer-related morbidity mortality highly targeted surveillance may be profound. Particularly important colonoscopy initiated at an early age (ie, 25 years) repeated annually accelerated carcinogenesis. In women, endometrial aspiration biopsy transvaginal ultrasound are given extraordinarily high ovarian carcinoma. These control strategies have major impact on at-risk members once they been counseled educated thoroughly about syndrome’s natural history their own risk.