Combined compared to dissociated oral and intestinal sucrose stimuli induce different brain hedonic processes

摘要: The characterization of brain networks contributing to the processing oral and/or intestinal sugar signals in a relevant animal model might help understand neural mechanisms related control food intake humans and suggest potential causes for impaired eating behaviors. This study aimed at comparing responses triggered by sucrose sensing pigs. Seven animals underwent single photon emission computed tomography (99mTc-HMPAO) further stimulation with neutral or artificial saliva paired saline infusion duodenum, proximal part intestine. Oral duodenal induced differential cerebral blood flow (CBF) changes regions known be involved memory, reward processes hedonic (i.e. pleasure) evaluation sensory stimuli, including dorsal striatum, prefrontal cortex, cingulate insular hippocampus parahippocampal cortex. Sucrose only combined similar activity patterns putamen, ventral anterior cortex hippocampus. Some deactivations cortices were detected presence stimulation. Finally, activation right was stimulation, while specific dissociated from caloric load. sheds new light on has implications unravel neuropsychological underlying pleasure motivation.