Viral participation in cellular and microenvironmental transformation and amplification towards malignancy in AIDS patients

摘要: HIV-1 infection would initially predispose to neoplastic transformation in terms of a progressive lymphocytic proliferation followed by the onset an immunodeficiency state. Both virion genomic integration and also active host cell perhaps participate establishment often multifocal primary CNS lymphoma AIDS type. Repeated opportunistic infections patients tend especially involve central nervous system carry increased risk reactive B lymphocytes reaching brain. A microenvironmental set circumstances with non-Hodgkin's largely that progresses concurrently evolving replication, immunodeficiency, repeated as caused several different potential pathogens. Epstein-Barr virus particular appears closely related Hodgkin's disease develops some patients. viral role development lymphomas Kaposi sarcoma HIV-infected individuals account for aggressiveness predilection lymphoma. Such implicates within genome cells are actively proliferating or else infected multiple pathogens such EBV, HIV-1, CMV, Herpes virus.