Deletions within the Epstein-Barr Virus Latent Membrane Protein-1 Oncogene in Adult Ordinary, HIV-Associated and Paediatric Hodgkin's Disease

摘要: The aims of this study were the following: a) to perform Epstein-Barr virus (EBV) strain type assignment in three groups Hodgkin's disease(HD): adult ordinary (39 cases), paediatric (24 and HIV-associated (30 cases) compare prevalence 1 2 each with that existing two reference populations made up 50 adults 39 children; b) assess frequency latent membrane protein-1 (LMP-1) 30-base pair (bp) deletions HD healthy controls; c) relate presence LMP-1 EBV type. Type was observed 12.8% HD, 26.7% 25% 4% controls, none children. existence double infections by also 5.1% 6.7% 10% controls. 30-bp deletion identified overall 33.3% 83.3% HIV-positive 79.2% 34.7% 36.4% Statistical analysis showed a significant association deleted strains occurring patients (P= 0.00003) childhood 0.006). On other hand, group reflects general population. Co-infections non-deleted detected 50% 26.5% 27.3% Concerning relationship between typing, 26% specimens carried an isolated manner compared 64.7% 2. statistical associated when coinfections excluded only cases which appeared alone considered (P=0.003).