Action potential propagation in a thick strand of cardiac muscle.

摘要: A theoretical model of action potential propagation in a thick strand cardiac muscle is presented. The calculation takes into account the anisotropic and syncytial properties tissue, presence interstitial space, effect surrounding tissue bath, variation both along length across cross section. bidomain used to represent electrical Ebihara-Johnson active sodium channels. calculated wave front curved, with at surface leading that center. rate rise time constant foot vary depth tissue. velocity nearly independent radius for radii greater than 0.5 mm. conduction decreases as volume fraction space decreases. In limit tightly packed cells, an propagates quickly over strand; bulk then excited by slow inward initiated on surface. This does not predict increase when cells are packed, hypothesis has been proposed previously explain fast Purkinje fibers some species.