A cleft model for cardiac Purkinje strands.

摘要: Conduction of the action potential in cardiac muscle is complicated by its multicellular structure, with narrow intercellular clefts and cell-to-cell coupling. A model developed from anatomical data to describe Purkinje strands variable diameter different internal arrangements cells. The admittance solved analytically fit results cable analysis. Using extracted specific membrane cell electrical parameters (Rm = 13 K omega cm2, Cm 1.5 mu F/cm2, Ri 100 cm, Re 50 cm), correctly predicted conduction velocity filling capacitance at onset a voltage step. analysis permits more complete studies factors controlling velocity; for instance, effect on capacity longitudinal current circuit discussed. Predictions impedance phase angle were also made. Measurements frequency dependence may provide basis separating cleft properties those surface aid measurement nonlinear muscle.