Antioxidant activity of calcium channel blocking drugs.
作者： I. Tong Mak , William B. Weglicki
DOI: 10.1016/0076-6879(94)34133-8
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摘要: Publisher Summary This chapter discusses the antioxidant activity of calcium channel blocking drugs. In common with most cardiovascular agents, clinically used blockers (nicardipine, nifedipine, verapamil, and diltiazem) are amphiphilic in nature. Thus, addition to their specific binding protein receptors, these agents may readily partition into phospholipid domain membranes various degrees according lipophilicity. Laboratory experiments have focused on effects such sensitivities cardiac vascular cells free radical injury. At membrane level, highly purified sarcolemmal ventricular myocytes as model membranes. Compared other subcellular membranes, much more sensitive radical-mediated damage, owing enriched content. To assess extent lipid peroxidation, thiobarbituric acid (TBA) method is because its sensitivity convenience.
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