Preparation and characterization of dendronized chitosan/gelatin-based nanogels

摘要: Abstract The composition, functionality and morphological structure of biomaterials control their properties, such as the hydrophilic/hydrophobic character, magnitude inter/intramolecular interaction, architecture size, which determine potential applications. adequate combination nanoscale with natural polymers could then yield nanogels (NGs) greater relevance for biomedicine. Also, dendritic structures can be combined NGs to improve Then, dendronized combine advantages hydrogels, multifunctionality, generating composite materials synergic properties. Dendronized polymer-based were prepared by inverse nanoemulsion. Gelatin chitosan crosslinked 0.3, 0.6 0.9 wt% tannic acid, weisisocyanate dendron. characterized using infrared microscopy, thermogravimetric analysis dynamic light scattering. IR spectra thermic allowed confirming crosslinking reaction acid dendronization NGs. systems are sized in nanometric scale within 100 500 nm, polydispersity index (PDI) values between 0.2 0.5. In all cases, an increase hydrodynamic diameter was observed degree a reduction size after up 100 nm. low obtained, showing value regulated crosslinker percentage, character governed moiety.