Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins.

摘要: The heterogeneous group of diseases collectively termed cancer results not just from aberrant cellular proliferation but also a lack accompanying homeostatic cell death. Indeed, cells regularly acquire resistance to programmed death, or apoptosis, which only supports progression leads therapeutic agents. Thus, various approaches have been undertaken in order induce apoptosis tumor for purposes. Here, we will focus our discussion on agents that directly affect the apoptotic machinery itself rather than drugs indirectly, such as by DNA damage kinase dependency inhibition. As roles Bcl-2 family extensively studied and reviewed recently, this review specifically inhibitor protein (IAP) family. IAPs are disparate proteins all contain baculovirus IAP repeat domain, is important inhibition some, all, members. We describe each members with respect their structural functional similarities differences respective cancer. Finally, current state targets anti-cancer therapeutics discuss clinical antagonists.