Translational Science Review Article Cardiomyopathy in a Dish: Using Human Inducible Pluripotent Stem Cells to Model Inherited Cardiomyopathies

作者： Daniel J. Garry , Mary G. Garry , Andre Klaassen Kamdar , Forum Kamdar , Naoko Koyano-Nakagawa

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摘要: Inherited cardiomyopathies, including hypertrophic cardiomyopathy, dilated arrythmogenic right ventricular and other inherited forms of heart failure, represent a unique set genetically defined cardiovascular disease processes. Unraveling the molecular mechanisms these deadly human has been challenging, but recent groundbreaking scientific advances in stem cell technology have allowed for generation patient-specific inducible (hiPSC)ederived cardiomyocytes (CMs). hiPSC-derived CMs retain genetic blueprint patient, they can be maintained culture, recapitulate phenotypic characteristics vitro, thus serving as dish. This review provides an overview vitro modeling cardiomyopathies with use CMs. (J Cardiac Fail 2015;21:761e770)

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参考文章(64)

Alan Colman, Hung-Fat Tse, Chung-Wah Siu, Yee-Ki Lee, Jenny Chung-Yee Ho, Wing-Hon Lai, Yau-Chi Chan, Kwong-Man Ng, Lai-Yung Wong, Ka-Wing Au, Yee-Man Lau, Jinqiu Zhang, Kenneth Weijian Lay, Modeling of lamin A/C mutation premature cardiac aging using patient-specific induced pluripotent stem cells Aging (Albany NY). ,vol. 4, pp. 803- 822 ,(2012) , 10.18632/AGING.100503

HG HERS, α-Glucosidase deficiency in generalized glycogen-storage disease (Pompe's disease) Biochemical Journal. ,vol. 86, pp. 11- 16 ,(1963) , 10.1042/BJ0860011

Kirsi Kujala, Jere Paavola, Anna Lahti, Kim Larsson, Mari Pekkanen-Mattila, Matti Viitasalo, Annukka M. Lahtinen, Lauri Toivonen, Kimmo Kontula, Heikki Swan, Mika Laine, Olli Silvennoinen, Katriina Aalto-Setälä, Cell Model of Catecholaminergic Polymorphic Ventricular Tachycardia Reveals Early and Delayed Afterdepolarizations PLoS ONE. ,vol. 7, pp. e44660- ,(2012) , 10.1371/JOURNAL.PONE.0044660

P.G. Barth, H.R. Scholte, J.A. Berden, J.M. Van Der Klei-Van Moorsel, I.E.M. Luyt-Houwen, E.Th. Van'T Veer-Korthof, J.J. Van Der Harten, M.A. Sobotka-Plojhar, An X-linked mitochondrial disease affecting cardiac muscle, skeletal muscle and neutrophil leucocytes Journal of the Neurological Sciences. ,vol. 62, pp. 327- 355 ,(1983) , 10.1016/0022-510X(83)90209-5

Ping Liang, Feng Lan, Andrew S. Lee, Tingyu Gong, Veronica Sanchez-Freire, Yongming Wang, Sebastian Diecke, Karim Sallam, Joshua W. Knowles, Paul J. Wang, Patricia K. Nguyen, Donald M. Bers, Robert C. Robbins, Joseph C. Wu, Drug Screening Using a Library of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity Circulation. ,vol. 127, pp. 1677- 1691 ,(2013) , 10.1161/CIRCULATIONAHA.113.001883

Steven J. Kattman, Alec D. Witty, Mark Gagliardi, Nicole C. Dubois, Maryam Niapour, Akitsu Hotta, James Ellis, Gordon Keller, Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell. ,vol. 8, pp. 228- 240 ,(2011) , 10.1016/J.STEM.2010.12.008

Atara Novak, Avraham Lorber, Joseph Itskovitz-Eldor, Ofer Binah, Modeling Catecholaminergic Polymorphic Ventricular Tachycardia using Induced Pluripotent Stem Cell-derived Cardiomyocytes Rambam Maimonides Medical Journal. ,vol. 3, ,(2012) , 10.5041/RMMJ.10086

Harry C. Dietz, New Therapeutic Approaches to Mendelian Disorders The New England Journal of Medicine. ,vol. 363, pp. 852- 863 ,(2010) , 10.1056/NEJMRA0907180

Ray E. Hershberger, Dale J. Hedges, Ana Morales, Dilated cardiomyopathy: the complexity of a diverse genetic architecture Nature Reviews Cardiology. ,vol. 10, pp. 531- 547 ,(2013) , 10.1038/NRCARDIO.2013.105

10.

Elisa Di Pasquale, Belle Song, Gianluigi Condorelli, Generation of human cardiomyocytes: a differentiation protocol from feeder-free human induced pluripotent stem cells. Journal of Visualized Experiments. ,(2013) , 10.3791/50429

Translational Science Review Article Cardiomyopathy in a Dish: Using Human Inducible Pluripotent Stem Cells to Model Inherited Cardiomyopathies

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Translational Science Review Article Cardiomyopathy in a Dish: Using Human Inducible Pluripotent Stem Cells to Model Inherited Cardiomyopathies

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