Activation of Ventrolateral Preoptic Neurons During Sleep
作者： J. E. Sherin , P. J. Shiromani , R. W. McCarley , C. B. Saper
DOI: 10.1126/SCIENCE.271.5246.216
关键词:
摘要: The rostral hypothalamus and adjacent basal forebrain participate in the generation of sleep, but neuronal circuitry involved this process remains poorly characterized. Immunocytochemistry was used to identify FOS protein, an immediate-early gene product, a group ventrolateral preoptic neurons that is specifically activated during sleep. retrograde tracer cholera toxin B, combination with immunocytochemistry, show sleep-activated innervate tuberomammillary nucleus, posterior hypothalamic cell thought modulation arousal. This monosynaptic pathway may play key role determining sleep-wake states.
sciencemag.org
harvard.edu
researchgate.net 参考文章(46)
E Senba, PE Daddona, T Watanabe, JY Wu, JI Nagy, None, Coexistence of adenosine deaminase, histidine decarboxylase, and glutamate decarboxylase in hypothalamic neurons of the rat The Journal of Neuroscience. ,vol. 5, pp. 3393- 3402 ,(1985) , 10.1523/JNEUROSCI.05-12-03393.1985
M. Pompeiano, C. Cirelli, G. Tononi, Fos-like immunoreactivity in the rat brain in spontaneous wakefulness and sleep. Archives Italiennes De Biologie. ,vol. 131, pp. 317- 326 ,(1993) , 10.4449/AIB.V131I4.797
W. J. H. Nauta, HYPOTHALAMIC REGULATION OF SLEEP IN RATS. AN EXPERIMENTAL STUDY Journal of Neurophysiology. ,vol. 9, pp. 285- 316 ,(1946) , 10.1152/JN.1946.9.4.285
Ronald Szymusiak, Dennis McGinty, Effects of basal forebrain stimulation on the waking discharge of neurons in the midbrain reticular formation of cats. Brain Research. ,vol. 498, pp. 355- 359 ,(1989) , 10.1016/0006-8993(89)91116-5
B.N. Mallick, G.S. Chhina, K.R. Sundaram, B. Singh, V.Mohan Kumar, Activity of preoptic neurons during synchronization and desynchronization Experimental Neurology. ,vol. 81, pp. 586- 597 ,(1983) , 10.1016/0014-4886(83)90328-X
M. Dragunow, R. Faull, The use of c-fos as a metabolic marker in neuronal pathway tracing. Journal of Neuroscience Methods. ,vol. 29, pp. 261- 265 ,(1989) , 10.1016/0165-0270(89)90150-7
M.B. Sterman, C.D. Clemente, Forebrain inhibitory mechanisms: cortical synchronization induced by basal forebrain stimulation. Experimental Neurology. ,vol. 6, pp. 91- 102 ,(1962) , 10.1016/0014-4886(62)90080-8
Naotoshi Murakami, Yoshihiro Sakai, Shigeki Ooki, Behavioral thermoregulation in rats during hyperthermia induced by lysergic acid diethylamide. Neuroscience Letters. ,vol. 20, pp. 105- 108 ,(1980) , 10.1016/0304-3940(80)90242-6
B.L. Krilowicz, R. Szymusiak, D. McGinty, Regulation of posterior lateral hypothalamic arousal related neuronal discharge by preoptic anterior hypothalamic warming Brain Research. ,vol. 668, pp. 30- 38 ,(1994) , 10.1016/0006-8993(94)90507-X
J K Elmquist, M R Ackermann, K B Register, R B Rimler, L R Ross, C D Jacobson, Induction of Fos-like immunoreactivity in the rat brain following Pasteurella multocida endotoxin administration Endocrinology. ,vol. 133, pp. 3054- 3057 ,(1993) , 10.1210/ENDO.133.6.8243337