Combined treatments of heat, radiation, or cytokines with flavone acetic acid on the growth of cultured endothelial cells.

摘要: The antitumour effects of flavone acetic acid (FAA) against a broad spectrum established experimental tumours has been demonstrated. Damage to the vasculature, which rapidly disrupts blood flow and induces haemorrhagic necrosis, is believed be major mechanism contributing observed effects. Despite these observations, FAA shown little effect human tumours. However, other applications FAA, for examples, an extended period treatments or in combination with modalities, have not sufficiently explored. In order test direct on endothelial cells isolated from umbilical vein (HUVEC) bovine pulmonary artery (CPAEC) were used this study. at concentrations 50 200 μg/ml causes reduction cell number (from 20 > 30% cells) HUVEC as measured by MTT assay after 1, 3, 5 h treatment 37°C. did produce significant similarly treated squ...