Seminal plasma and male factor signalling in the female reproductive tract

摘要: In mammals, insemination results in the transmission of seminal factors that act, female reproductive tract, to promote sperm survival, “condition” immune response tolerate conceptus and organise molecular cellular changes endometrium facilitate embryo development implantation. These events are initiated when signalling agents, including transforming growth factor-β other cytokines prostaglandins secreted by vesicle prostate glands, interact with epithelial cells cervix uterus activate cytokine synthesis induce resembling a classical inflammatory cascade. The consequences recruitment activation macrophages, granulocytes dendritic cells, which have immune-regulatory tissue-remodelling roles culminate improved endometrial receptivity implanting embryo. Cytokines elicited embryotrophic properties also contribute directly optimal early This review summarises our current understanding physiology responses plasma tract considers evolutionary significance influencing tissues success pregnancy.