Clinical pharmacokinetics and pharmacodynamics of colloidal plasma volume expanders

摘要: The pharmacokinetics and pharmacodynamics of albumin, hetastarch, pentastarch, dextrans are determined by different factors. Albumin's effects controlled movement the protein between vascular extravascular pools. kinetics dynamics hetastarch a new plasma expander, more extent hydroxyethylation (ie, molar substitution) than molecular weight fracions. Pentastarch, because its lower substitution distribution, is eliminated from body at much faster rate hetastarch. In contrast, dextran's duration effect fractions. A review available data indicates that 6% comparable to dextran 70 in volume expansion. Their last 12 24 hours comparison with eight for 10% pentastarch only four six 5% albumin. amount expansion appears be greatest (100% 150% infused volume), followed 125%), (100%), albumin (80% 100%).