Physiological aspects of the role of human albumin in the treatment of chronic and acute blood loss.

摘要: Human albumin is the most important oncotic-active protein (1 g attaches 18 water). It essential for water exchange between intra- and extracellular space homeostasis. The physiological distribution of albumin, its daily degradation are being discussed. At example normo- hypovolaemic patients acute blood-loss stabilising effect on blood-volume hemodynamic efficacy human shown. was infused into with hypoproteinemia hypovolaemia as well to surgical normovolaemia. Volunteers received after an blood-loss. Under albumin-infusion disappeared partly from blood-stream. loss extravascular compartments greatest among hypoproteinemia. Among volunteers experimental volume in amount 45 106 ml per hour. When given over a longer period synthesis endogenous globulins may be inhibited or at least depressed. Albumin has positive hemodynamic. cardiac-output stroke increased. peripheral resistance fell same time. Renal filtration rate urine increased, contrast renal lowered.