Functional annotations for the Saccharomyces cerevisiae genome: the knowns and the known unknowns

作者: Karen R. Christie , Eurie L. Hong , J. Michael Cherry

DOI: 10.1016/J.TIM.2009.04.005

关键词:

摘要: The quest to characterize each of the genes yeast Saccharomyces cerevisiae has propelled development and application novel high-throughput (HTP) experimental techniques. To handle enormous amount information generated by these techniques, new bioinformatics tools resources are needed. Gene Ontology (GO) annotations curated Genome Database (SGD) have facilitated algorithms that analyze HTP data help predict functions for poorly characterized in S. other organisms. Here, we describe how published results incorporated into GO at SGD why researchers can benefit from using wisely their gene functions.

参考文章(73)
John D. Osborne, Lihua (Julie) Zhu, Simon M. Lin, Warren A. Kibbe, Interpreting Microarray Results With Gene Ontology and MeSH Methods of Molecular Biology. ,vol. 377, pp. 223- 241 ,(2007) , 10.1007/978-1-59745-390-5_14
Michael Ashburner, Catherine A Ball, Judith A Blake, H Butler, JM Cherry, J Corradi, K Dolinski, JT Eppig, MA Harris, DP Hill, S Lewis, B Marshall, C Mungall, L Reiser, S Rhee, JE Richardson, J Richter, Martin Ringwald, Gerald M Rubin, Gavin Sherlock, J Yoon, Creating the gene ontology resource: design and implementation. pp. 1425- ,(2001)
Leland H. Hartwell, John J. Hopfield, Stanislas Leibler, Andrew W. Murray, From molecular to modular cell biology. Nature. ,vol. 402, ,(1999) , 10.1038/35011540
G Lynn Law, Kellie S Bickel, Vivian L MacKay, David R Morris, The undertranslated transcriptome reveals widespread translational silencing by alternative 5' transcript leaders Genome Biology. ,vol. 6, pp. 1- 15 ,(2005) , 10.1186/GB-2005-6-13-R111
Alexandre Gattiker, Riccarda Rischatsch, Philippe Demougin, Sylvia Voegeli, Fred S Dietrich, Peter Philippsen, Michael Primig, Ashbya Genome Database 3.0: a cross-species genome and transcriptome browser for yeast biologists. BMC Genomics. ,vol. 8, pp. 9- 9 ,(2007) , 10.1186/1471-2164-8-9
Roger W Kramer, Naomi L Slagowski, Ngozi A Eze, Kara S Giddings, Monica F Morrison, Keri A Siggers, Michael N Starnbach, Cammie F Lesser, Yeast functional genomic screens lead to identification of a role for a bacterial effector in innate immunity regulation. PLOS Pathogens. ,vol. 3, ,(2007) , 10.1371/JOURNAL.PPAT.0030021
Patrick O. Brown, David Botstein, Exploring the new world of the genome with DNA microarrays Nature Genetics. ,vol. 21, pp. 33- 37 ,(1999) , 10.1038/4462
Satoru Nogami, Yoshikazu Ohya, Gaël Yvert, Genetic complexity and quantitative trait loci mapping of yeast morphological traits. PLOS Genetics. ,vol. 3, ,(2007) , 10.1371/JOURNAL.PGEN.0030031
Mark D Robinson, Nicholas Mitsakakis, Mark Johnston, Timothy R Hughes, The promise of functional genomics: completing the encyclopedia of a cell Current Opinion in Microbiology. ,vol. 7, pp. 546- 554 ,(2004) , 10.1016/J.MIB.2004.08.015
Hoon Park, Yoon-Sun Hwang, Genome-wide transcriptional responses to sulfite in Saccharomyces cerevisiae The Journal of Microbiology. ,vol. 46, pp. 542- 548 ,(2008) , 10.1007/S12275-008-0053-Y