Genome-wide transcriptional responses to sulfite in Saccharomyces cerevisiae
作者： Hoon Park , Yoon-Sun Hwang
DOI: 10.1007/S12275-008-0053-Y
关键词:
摘要: Sulfite is a commonly used preservative in foods, beverages, and Pharmaceuticals because it toxic to many microorganisms. In order understand the global response of Saccharomyces cerevisiae sulfite, genome-wide transcript profiling following sulfite exposure was obtained. The transcription levels 21 genes were increased more than 2-fold, while those 37 decreased similar extent. Genes involved carbohydrate metabolism represented highest proportion induced genes, which may account for easily acquired resistance sulfite. Most down-regulated are transcription, protein biosynthesis, cell growth. down-regulation these thought reflect growth arrest occurs during treatment, allowing cells save energy. Cells treated with generated 70% acetaldehyde untreated cells, suggesting that production correlated induction PDC1 gene encoding pyruvate decarboxylase.
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