Differential regulation of cardiac angiotensin converting enzyme binding sites and AT1 receptor density in the failing human heart.
作者： Lawrence S. Zisman , Koji Asano , Darrin L. Dutcher , Anthony Ferdensi , Alastair D. Robertson
DOI: 10.1161/01.CIR.98.17.1735
关键词:
摘要: Background—The regulation and interaction of ACE the angiotensin II (Ang II) type I (AT1) receptor in failing human heart are not understood. Methods Results—Radioligand binding with 3H-ramiprilat was used to measure protein membrane preparations hearts obtained from 36 subjects idiopathic dilated cardiomyopathy (IDC), 8 primary pulmonary hypertension (PPH), 32 organ donors normal cardiac function (NF hearts). 125I-Ang formation measured a subset hearts. Saralasin (125I-{Sar1,Ile8}-Ang total Ang density. AT1 AT2 were determined antagonist losartan. Maximal (Bmax) 578±47 fmol/mg IDC left ventricle (LV), 713±97 PPH LV, 325±27 NF LV (P<0.001, or versus NF). In IDC, PPH, right ventricles (RV), Bmax 737±78, 638±137, 422±49 fmol/mg, respectively (P=0.02, NF; P=0.08, 125I-Ang...
sci-hub.se 参考文章(24)
L. Wei, F. Alhenc-Gelas, P. Corvol, E. Clauser, The two homologous domains of human angiotensin I-converting enzyme are both catalytically active. Journal of Biological Chemistry. ,vol. 266, pp. 9002- 9008 ,(1991) , 10.1016/S0021-9258(18)31543-6
K K Griendling, B Lassègue, T J Murphy, M Clark, R W Alexander, G Nickenig, Angiotensin II down-regulates the vascular smooth muscle AT1 receptor by transcriptional and post-transcriptional mechanisms: evidence for homologous and heterologous regulation. Molecular Pharmacology. ,vol. 48, pp. 601- 609 ,(1995)
T. Vago, M. Bevilacqua, F. Conci, G. Baldi, E. Ongini, E. Chebat, A. Monopoli, G. Norbiato, Angiotensin converting enzyme binding sites in human heart and lung: comparison with rat tissues. British Journal of Pharmacology. ,vol. 107, pp. 821- 825 ,(1992) , 10.1111/J.1476-5381.1992.TB14530.X
Guoping Cai, Hakan Gurdal, Tammy M. Seasholtz, Mark D. Johnson, Age-related changes in angiotensin II-stimulated vascular contraction and inositol phosphate accumulation in Fischer 344 rats. Mechanisms of Ageing and Development. ,vol. 76, pp. 125- 133 ,(1994) , 10.1016/0047-6374(94)91587-3
A. H. Jan Danser, Catharina A. M. van Kesteren, Willem A. Bax, Monique Tavenier, Frans H. M. Derkx, Pramod R. Saxena, Maarten A. D. H. Schalekamp, Prorenin, renin, angiotensinogen, and angiotensin-converting enzyme in normal and failing human hearts. Evidence for renin binding. Circulation. ,vol. 96, pp. 220- 226 ,(1997) , 10.1161/01.CIR.96.1.220
R. PACHER, S. GLOBITS, J. BERGLER-KLEIN, H. TEUFELSBAUER, M. WUTTE, W. BAUMGARTNER, E. OGRIS, D. GLOGAR, Clinical and neurohumoral response of patients with severe congestive heart failure treated with two different captopril dosages. European Heart Journal. ,vol. 14, pp. 273- 278 ,(1993) , 10.1093/EURHEARTJ/14.2.273
Arlene Wolny, Jean-Paul Clozel, Josiane Rein, Paul Mory, Paul Vogt, Marko Turino, Wolfgang Kiowski, Walter Fischli, Functional and Biochemical Analysis of Angiotensin II–Forming Pathways in the Human Heart Circulation Research. ,vol. 80, pp. 219- 227 ,(1997) , 10.1161/01.RES.80.2.219
Seiji Hokimoto, Hirofumi Yasue, Kazuteru Fujimoto, Hideyuki Yamamoto, Koichi Nakao, Koichi Kaikita, Ryuzo Sakata, Eishichi Miyamoto, Expression of Angiotensin-Converting Enzyme in Remaining Viable Myocytes of Human Ventricles After Myocardial Infarction Circulation. ,vol. 94, pp. 1513- 1518 ,(1996) , 10.1161/01.CIR.94.7.1513
M. Nakajima, H. G. Hutchinson, M. Fujinaga, W. Hayashida, R. Morishita, L. Zhang, M. Horiuchi, R. E. Pratt, V. J. Dzau, The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 10663- 10667 ,(1995) , 10.1073/PNAS.92.23.10663
Mechthild Falkenhahn, Folker Franke, Rainer Maria Bohle, Yi-Chun Zhu, Harald Martin Stauss, Sebastian Bachmann, Sergei Danilov, Thomas Unger, Cellular distribution of angiotensin-converting enzyme after myocardial infarction. Hypertension. ,vol. 25, pp. 219- 226 ,(1995) , 10.1161/01.HYP.25.2.219