Prorenin, renin, angiotensinogen, and angiotensin-converting enzyme in normal and failing human hearts. Evidence for renin binding.

摘要: Background A local renin-angiotensin system in the heart is often invoked to explain beneficial effects of ACE inhibitors failure. The heart, however, produces little or no renin under normal conditions. Methods and Results We compared cardiac tissue levels components 10 potential donors who died noncardiac disorders subjects with dilated cardiomyopathy (DCM) underwent transplantation. Cardiac prorenin DCM patients were higher than donors. plasma positively correlated, extrapolation regression line yielded a level close that measured donor hearts. tissue-to-plasma concentration (T/P) ratios for threefold ratio albumin, which indicates too high be accounted by admixture blood diffusion into interstitial fluid. Cell me...