Supraregional Interlaboratory Quality-Control Survey for an Immunoradiometric Renin Assay

摘要: For the last 20 years, most widely used method for assessment of renin-angiotensin system has been plasma renin activity assay (1). Although gives useful information on enzymatic function molecule, intrinsic characteristics this limit its analytical accuracy (2). Immunoradiometric assays renin, developed in 1985, overcame limitation because well-defined monoclonal antibodies provided means direct quantification specific active forms enzyme molecule (3)(4). Nevertheless, a critical debate over use these (5)(6)(7)(8)(9)(10). A pilot study (11)(12) limited number laboratories (eight Italian centers) found satisfactory indexes precision immunoradiometric (Eria Diagnostics, Sanofi-Pasteur). In our previous experience, inter- and intralaboratory reproducibility indices commercial appeared to be better than those that had achieved with an (REN-CTK; Sorin Biomedica), differences probably being attributable greater complexity procedure latter (11). Various reports have published during past 30 years describing tools monitor performance immunoassays …