Effects of sulfonylureas on lipids in type 2 diabetes mellitus: a meta-analysis of randomized controlled trials

摘要: Objective Previous studies suggested that dyslipidemia was potentially associated with anti-diabetic medications of sulfonylureas (SUs). The results were, however, inconsistent. Therefore, we conducted a meta-analysis randomized controlled trials (RCTs) to assess the effects SUs on level lipids in patients type 2 diabetes mellitus (T2DM). Methods We searched PubMed, EMBASE, and CENTRAL databases for RCTs addressed second- and/or third-generation used T2DM profiles study duration at least 12 weeks. Two reviewers independently screened literature, collected data, assessed methodological quality included studies. performed by using RevMan5.1 software. Results A total 59 were included, which 52 final meta-analysis. statistically increased levels FFA (SMD = 0.24, 95%CI 0.06 0.42) TG (MD 0.06, 0.02 0.10), but decreased HDL-C −0.07, −0.11 −0.04) LDL-C −0.11, −0.17 −0.04); had no effect TC 0.01, −0.05 0.08), ApoA1 −0.03 0.04), Apo B −0.01, 0.03). When compared metformin, could increase LDL-C; glinides, lowered HDL-C; thiazolidinediones, reduced TC, LDL-C, HDL-C, TG. Conclusions SUs have small lipids, although they may TG, decrease HDL-C.