Residual metals cause variability in methionine oxidation measurements in protein pharmaceuticals using LC-UV/MS peptide mapping

作者: Li Zang , Tyler Carlage , David Murphy , Ruth Frenkel , Peter Bryngelson

DOI: 10.1016/J.JCHROMB.2012.03.016

关键词:

摘要: … The following digestion buffers were compared for their effect on the methionine oxidation using multiple IgG1 and IgG4 antibody molecules: 50 mM sodium phosphate, pH 7.2; 5 mM …

参考文章(21)
Jennifer L Liu, Kan V Lu, Tamer Eris, Viswanatham Katta, Keith R Westcott, Linda O Narhi, Hsieng S Lu, None, In vitro methionine oxidation of recombinant human leptin. Pharmaceutical Research. ,vol. 15, pp. 632- 640 ,(1998) , 10.1023/A:1011998331254
Mark C. Manning, Kamlesh Patel, Ronald T. Borchardt, Stability of Protein Pharmaceuticals Pharmaceutical Research. ,vol. 6, pp. 903- 918 ,(1989) , 10.1023/A:1015929109894
Daniel J. Kroon, Alysia Baldwin‐Ferro, Praful Lalan, Identification of sites of degradation in a therapeutic monoclonal antibody by peptide mapping. Pharmaceutical Research. ,vol. 9, pp. 1386- 1393 ,(1992) , 10.1023/A:1015894409623
Vladislav Dolník, Katariina M. Hutterer, Capillary electrophoresis of proteins 1999–2001 Electrophoresis. ,vol. 22, pp. 4163- 4178 ,(2001) , 10.1002/1522-2683(200111)22:19<4163::AID-ELPS4163>3.0.CO;2-9
Mark Cornell Manning, Danny K. Chou, Brian M. Murphy, Robert W. Payne, Derrick S. Katayama, Stability of Protein Pharmaceuticals: An Update Pharmaceutical Research. ,vol. 27, pp. 544- 575 ,(2010) , 10.1007/S11095-009-0045-6
Hongcheng Liu, Georgeen Gaza-Bulseco, Tao Xiang, Chris Chumsae, Structural effect of deglycosylation and methionine oxidation on a recombinant monoclonal antibody Molecular Immunology. ,vol. 45, pp. 701- 708 ,(2008) , 10.1016/J.MOLIMM.2007.07.012
Colette A. Sacksteder, Jennifer E. Whittier, Yijia Xiong, Jinhui Li, Nadezhda A. Galeva, Michael E. Jacoby, Samuel O. Purvine, Todd D. Williams, Martin C. Rechsteiner, Diana J. Bigelow, Thomas C. Squier, Tertiary Structural Rearrangements upon Oxidation of Methionine145 in Calmodulin Promotes Targeted Proteasomal Degradation Biophysical Journal. ,vol. 91, pp. 1480- 1493 ,(2006) , 10.1529/BIOPHYSJ.106.086033
Damian Houde, Paivi Kauppinen, Rohin Mhatre, Yelena Lyubarskaya, Determination of protein oxidation by mass spectrometry and method transfer to quality control. Journal of Chromatography A. ,vol. 1123, pp. 189- 198 ,(2006) , 10.1016/J.CHROMA.2006.04.046
Shihong Li, Tue H. Nguyen, Christian Schoneich, Ronald T. Borchardt, Aggregation and Precipitation of Human Relaxin Induced by Metal-Catalyzed Oxidation Biochemistry. ,vol. 34, pp. 5762- 5772 ,(1995) , 10.1021/BI00017A008