Fuchs' endothelial dystrophy: a fresh look at an aging disease.

摘要: The increasing number or corneal and intraocular surgeries performed together with longer life expectancy, elevates the risk for developing symptomatic Fuchs' endothelial dystrophy (FED). This article reviews current understanding of FED, and, in addition, a case early FED is presented clinically histopathologically. Two corneas from one patient were examined histopathologically using an established histological protocol light electron microscopy. inherited autosomal dominant disorder incomplete penetrance that up to 3 times less likely develop men. Treatment options are primarily palliative while surgical intervention routinely involves penetrating keratoplasty. In this disease process endothelium produces excessive amounts basement membrane material abnormal composition resulting formation posterior collagenous layer. Extreme accumulations created mushroom-like formations, guttae, projecting into anterior chamber. cells extremely thinned over point where may provide little more than barrier function. Despite presumably compromised pump appeared relatively free edema However, some edematous pockets deep basal epithelial layer present suggesting involvement occurs at stage disease. An diagnosis will help patients surgeons better elect optimal timing procedures. trend intervene surgically before reaches painful end-stage. Interestingly, examined, provided only function large areas apparently reduced contribution fluid yet remained clear. Future research confirm decompensation when complete coverage lost. If important transparency then relative combination these two functions normal cornea should also be reassessed.