Benzodiazepines in pregnancy--academical debate or teratogenic risk?

摘要: Benzodiazepines are presently the most widely prescribed drugs. They considered as safe drugs although there is appreciable evidence from animal experiments well epidemiological evaluations that they act teratogens. The pertinent literature subjected to a synopsis with results pharmacological, biochemical and behavioral research. Recent views of mechanisms teratogenic action serve propose several points attack where benzodiazepines can disturb development central nervous system. This take place during organogenesis, early differentiation neural anlagen after tube closure or brain. It suggested intake at any time pregnancy may result in visible malformations, functional deficits anomalies exposed children.