Homocysteine levels are associated with hippocampus volume in type 2 diabetic patients

摘要: Eur J Clin Invest 2011; 41 (7): 751–758 Abstract Background  Elevated total plasma homocysteine (tHcy) levels are associated with cognitive dysfunction, in which changes the hippocampus plausibly play a pivotal role. We tested hypothesis that elevated tHcy correlated volume and insulin resistance nondementia patients type 2 diabetes. Materials methods  The study included 43 diabetes, who were divided into two groups: high group (age: 65 ± 8 years, mean ± standard deviation, n = 16) normal (64 ± 9 years, n = 27). Hippocampus was quantified computer-assisted analysis using magnetic resonance imaging (MRI) voxel-based specific regional system developed for of Alzheimer’s disease (VSRAD), yields Z-score as end point assessment hippocampal volume. Results  higher compared to (P < 0·0001). fasting glucose (P < 0·01) (P < 0·0001) concentrations homoeostasis model (HOMA) index than group. Multiple regression showed main factors influenced may be HOMA index. Conclusions  Our results indicate Japanese diabetes characterised by atrophy primary influence levels.