Regulation of heat shock protein 70 gene expression by c-myc.
作者： Robert E. Kingston , Albert S. Baldwin , Phillip A. Sharp
DOI: 10.1038/312280A0
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摘要: The myc gene seems to have a causal role in tumour formation man, mouse and avian systems1–3. product has been localized the nucleus4,5, suggesting that it may be involved regulation of expression. level expression mammalian heat shock protein 70 (HSP70) is elevated several cell lines6, implying cellular function expressed these lines can stimulate HSP70 production. We report here rearranged c-myc capable stimulating chimaeric genes containing Drosophila hsp70 promoter region 5′-flanking sequences. This stimulation dependent on sequences located more than 200 bases 5′ normal start transcription.
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