The impact of FOXO on dopamine and octopamine metabolism in Drosophila under normal and heat stress conditions

摘要: ABSTRACT The forkhead boxO transcription factor (FOXO) is a component of the insulin signalling pathway and plays role in responding to adverse conditions, such as oxidative stress starvation. In stressful FOXO moves from cytosol nucleus where it activates gene expression programmes. Here, we show that Drosophila melanogaster responds heat does other stressors. catecholamine another response. , dopamine octopamine levels rise steeply under heat, nutrition mechanical stresses, which are followed by decrease activity synthesis enzymes. We demonstrate nearly twofold decline foxo BG01018 mutants results dramatic changes metabolism overall response stress. absence increases tyrosine decarboxylase activity, first enzyme synthesis, decreases enzymatic enzymes alkaline phosphatase hydroxylase, young females. identified juvenile hormone mediator regulation metabolism. Our findings suggest possible trigger for endocrinological reactions.