Evidence for antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication.
作者： K D Croen
DOI: 10.1172/JCI116479
关键词:
摘要: Nitric oxide (NO) has antimicrobial activity against a wide spectrum of infectious pathogens, but an antiviral effect not been reported. The impact NO, from endogenous and exogenous sources, on herpes simplex virus type 1 (HSV 1) replication was studied in vitro. HSV RAW 264.7 macrophages reduced 1,806-fold monolayers induced to make NO by activation with gamma IFN LPS. A competitive noncompetitive inhibitor nitric synthetase substantially the activated macrophages. S-nitroso-L-acetyl penicillamine (SNAP) is donor added media infected assess properties absence single dose 3 h after infection inhibited Vero, HEp2, cells dose-dependent manner. Neither virucidal nor cytocidal effects were observed under conditions that replication. had inhibitory effects, comparable IFN/LPS, protein DNA synthesis as well cell This report demonstrates that, among its diverse properties, effect.
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