CRISPR-Cas component systems, methods and compositions for sequence manipulation
作者： David Olivier Bikard , Luciano Marraffini , Le Cong , Neville Espi Sanjana , Wenyan Jiang
DOI:
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摘要: The invention provides for systems, methods, and compositions manipulation of sequences and/or activities target sequences. Provided are vectors vector some which encode one or more components a CRISPR complex, as well methods the design use such vectors. Also provided directing complex formation in eukaryotic cells selecting specific by introducing precise mutations utilizing CRISPR/Cas system.
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