Multitargeting Compounds: A Promising Strategy to Overcome Multi-Drug Resistant Tuberculosis.

摘要: Tuberculosis is still an urgent global health problem, mainly due to the spread of multi-drug resistant M. tuberculosis strains, which lead need new more efficient drugs. A strategy overcome problem resistance insurgence could be polypharmacology approach, develop single molecules that act on different targets. Polypharmacology have features make it approach effective than classical polypharmacy, in drugs with high affinity for one target are taken together. Firstly, a compound has multiple targets, probability development should considerably reduced. Moreover, such compounds higher efficacy, and show synergic effects. Lastly, use molecule conceivably associated lower risk side effects, problems drug–drug interaction. Indeed, multitargeting novel antitubercular gained great interest recent years. This review article aims provide overview most promising drug candidates.