Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases

作者: Kai Li , Lici A. Schurig-Briccio , Xinxin Feng , Ashutosh Upadhyay , Venugopal Pujari

DOI: 10.1021/JM500131S

关键词:

摘要: We report the discovery of a series of new drug leads that have potent activity against Mycobacterium tuberculosis as well as against other bacteria, fungi, and a malaria parasite. The …

参考文章(41)
Rafael Moreno-Sánchez, Concepción Bravo, César Vásquez, Guadalupe Ayala, Luis H Silveira, Manuel Martı́nez-Lavı́n, Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs: study in mitochondria, submitochondrial particles, cells, and whole heart. Biochemical Pharmacology. ,vol. 57, pp. 743- 752 ,(1999) , 10.1016/S0006-2952(98)00330-X
Cedric P. Owens, Nicholas Chim, Amanda B. Graves, Christine A. Harmston, Angelina Iniguez, Heidi Contreras, Matthew D. Liptak, Celia W. Goulding, The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11. Journal of Biological Chemistry. ,vol. 288, pp. 21714- 21728 ,(2013) , 10.1074/JBC.M113.453076
William S.J. Valdar, Scoring residue conservation. Proteins. ,vol. 48, pp. 227- 241 ,(2002) , 10.1002/PROT.10146
Richard B. Moon, John H. Richards, Determination of intracellular pH by 31P magnetic resonance. Journal of Biological Chemistry. ,vol. 248, pp. 7276- 7278 ,(1973) , 10.1016/S0021-9258(19)43389-9
Morris O. Makobongo, Leo Einck, Richard M. Peek, D. Scott Merrell, In Vitro Characterization of the Anti-Bacterial Activity of SQ109 against Helicobacter pylori PLoS ONE. ,vol. 8, pp. e68917- ,(2013) , 10.1371/JOURNAL.PONE.0068917
K. C. Gray, D. S. Palacios, I. Dailey, M. M. Endo, B. E. Uno, B. C. Wilcock, M. D. Burke, Amphotericin primarily kills yeast by simply binding ergosterol Proceedings of the National Academy of Sciences of the United States of America. ,vol. 109, pp. 2234- 2239 ,(2012) , 10.1073/PNAS.1117280109
J. H. No, F. de Macedo Dossin, Y. Zhang, Y.-L. Liu, W. Zhu, X. Feng, J. A. Yoo, E. Lee, K. Wang, R. Hui, L. H. Freitas-Junior, E. Oldfield, Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity Proceedings of the National Academy of Sciences of the United States of America. ,vol. 109, pp. 4058- 4063 ,(2012) , 10.1073/PNAS.1118215109
Lynn L Silver, Multi-targeting by monotherapeutic antibacterials. Nature Reviews Drug Discovery. ,vol. 6, pp. 41- 55 ,(2007) , 10.1038/NRD2202