Reciprocal regulation of CD30 expression on CD4+ T cells by IL-4 and IFN-gamma.

摘要: Prior studies have implicated CD30 as a marker for Th2 cells, but the mechanism that underlies this correlation was unknown. We show here expressed on activated CD4+ T cells in presence of IL-4. In absence endogenously produced IL-4, however, even lineage lost expression. Thus, is not an intrinsic inducible by also found to be down-regulated IFN-gamma. Committed Th1 effector do express CD30, although differentiating temporarily CD30. The transient expression mainly result IL-4 induced IL-12. Culture IL-12-primed under conditions reverse phenotype (Ag plus IL-4) resulted two cell populations based upon their ability One population responded restimulation and became CD30-positive, Th0-like population, while other remained negative synthesized only reflected respond