Islet cell dysfunction in patients with chronic pancreatitis.

摘要: Chronic pancreatitis (CP) is characterized by progressive inflammation and fibrosis of the pancreas that eventually leads to pancreatic exocrine endocrine insufficiency. Diabetes in background CP very difficult manage due high glycemic variability concomitant malabsorption. Progressive beta cell loss leading insulin deficiency cardinal mechanism underlying diabetes development CP. Alpha dysfunction deranged glucagon secretion has been described different studies using a variety stimuli However, emerging evidence varied probably because dependence on study procedure, population as well stage disease. The behind islet multifactorial. intra-islet alpha regulation each other often lost. Moreover, incretin hormones such like peptide-1 glucose-dependent insulinotropic polypeptide dysregulated. This significantly contributes disturbances. Persistent with changes function cells delta are also implicated In addition, surgical procedures performed patients antihyperglycemic drugs used treat associated affect function. Hence, factors chronic inflammation, dysregulated axis, interventions anti-diabetic all Newer therapies targeting regeneration would be useful management near future.