Antifilarial activity of intravenous suramin and oral diethylcarbamazine citrate on subperiodic Brugia malayi in the leaf-monkey, Presbytis cristata

摘要: The known filaricides, suramin and diethylcarbamazine citrate, were tested against subperiodic Brugia malayi infection in the leaf-monkey, Presbytis cristata. As expected, intravenous at 10 mg/kg daily x 5 days or 17 weekly weeks, did not show any microfilaricidal activity, but substantially reduced recovery of live adult worms to 50.6% 13.6% controls respectively. Oral citrate 6 final microfilarial counts 30% initial four weeks post-treatment worm was 4.5% 0% Although antifilarial activity these drugs this non-human primate model appears be similar that seen man, results have confirmed using larger groups animals.