The mode of action of suramin on the filarial worm Brugia pahangi.

摘要: The mode of action suramin upon Brugia pahangi has been investigated in vivo and vitro. drug was without effect on the glycolytic activity worms vitro at 2 X 10(-4) M. lack correlated with failure [14C]suramin to penetrate Suramin bound surface presumably by virtue its polyanionic nature. B. adults ingested but no reduction rate lactate production, glucose utilization or rates uptake [14C]glucose, [14C]leucine [14C]adenosine observed recovered from jirds between weeks 1 5 following 4 daily doses 50 mg/kg given intraperitoneally. Worm death occurred 7 this delayed not result a progressive accumulation worms. Ultrastructural changes were intestinal epithelium suramin-treated parallel observations exposed Trypan blue suggest that both compounds are restricted lumen evidence presented is consistent concept that, pahangi, acts primarily inhibiting catabolism phagosome lysosome fusion as previously demonstrated for bloodstream trypanosomes mammalian macrophages, respectively.