The effects of ivermectin used in combination with other known antiparasitic drugs on adult Onchocerca gutturosa and O. volvulus in vitro.

摘要: The effects of ivermectin at a concentration 3.13 x 10(-6) M used in combination with other antiparasitic drugs on the viability adult Onchocerca vitro were assessed using MTT colorimetry and worm motility levels. When was against male O. gutturosa over 7 d period suramin (5 10(-5) M), CGP 6140 (3.13 20376 (1.95 10(-7) mefloquine levamisole mebendazole flubendazole M) albendazole there either no increased effect or only marginally levels when compared use alone. revealed that most cases cumulative 2 but not synergistic effect. In trial extended to 26 it demonstrated did produce greater inhibition than Using female volvulus, activity ivermectin, combined examined. all 3 groups exposed drug(s) suppressed by 24 h controls. performed day 7, pre-weighed anterior end each worm, illustrated alone produced 43.4% formazan formation controls, 50.6% inhibition, while drug 72% equivalent heat-killed control.(ABSTRACT TRUNCATED AT 250 WORDS)