Steviol, a natural product inhibits proliferation of the gastrointestinal cancer cells intensively.
作者： Junming Chen , Yongmei Xia , Xiaochen Sui , Qingrui Peng , Tongtong Zhang
DOI: 10.18632/ONCOTARGET.25233
关键词:
摘要: New anticancer agents with lower toxicity have been always urged because of drug resistance associated overused chemotherapy agents. In this study, steviol, a colonic metabolite natural sweetener and also component in leaves stevia rebaudiana bertoni, was found to possess intensive activity on the human gastrointestinal cancer cells. Steviol inhibited six cells intensively as 5-fluorouracil did at 100 μg/mL. The inhibition mechanism follows mitochondrial apoptotic pathway that evidenced by increase Bax/Bcl-2 ratio, activation p21 p53; caspase 3-independent involved. These results are consistent miRNA expression analysis. most regulated miRNAs steviol treated were miR-203a-3p (log2 =1.32) miR-6088 =-2.54) HCT-116, miR-1268b =19.85) miR-23c =-2.05) MKN-45. view metabolic characteristics its cytotoxicity cells, could be agent potentially for treatment.
sci-hub.se 参考文章(37)
Jane A. Plumb, Cell sensitivity assays: the MTT assay. Methods in molecular medicine. ,vol. 88, pp. 165- 169 ,(2004) , 10.1385/1-59259-406-9:165
Alessandra Tessitore, Germana Cicciarelli, Valentina Mastroiaco, Filippo Del Vecchio, Daria Capece, Daniela Verzella, Mariafausta Fischietti, Davide Vecchiotti, Francesca Zazzeroni, Edoardo Alesse, Therapeutic Use of MicroRNAs in Cancer Anti-cancer Agents in Medicinal Chemistry. ,vol. 16, pp. 7- 19 ,(2015) , 10.2174/1871520615666150824153358
Tomoko Hashimoto-Tamaoki, Jun-ichi Furuyama, Takehira Yamamura, Masafumi Noda, Hidenori Yanagi, Reigetsu Yoshikawa, Masato Kusunoki, Dual antitumor effects of 5-fluorouracil on the cell cycle in colorectal carcinoma cells: a novel target mechanism concept for pharmacokinetic modulating chemotherapy. Cancer Research. ,vol. 61, pp. 1029- 1037 ,(2001)
Olaf Wolkenhauer, Ali Farazmand, Raheleh Amirkhah, Ulf Schmitz, Michael Linnebacher, MicroRNA-mRNA interactions in colorectal cancer and their role in tumor progression. Genes, Chromosomes and Cancer. ,vol. 54, pp. 129- 141 ,(2015) , 10.1002/GCC.22231
Marietta Wolter, Thomas Werner, Bastian Malzkorn, Guido Reifenberger, Role of microRNAs Located on Chromosome Arm 10q in Malignant Gliomas. Brain Pathology. ,vol. 26, pp. 344- 358 ,(2016) , 10.1111/BPA.12294
S Zinkel, A Gross, E Yang, BCL2 family in DNA damage and cell cycle control. Cell Death & Differentiation. ,vol. 13, pp. 1351- 1359 ,(2006) , 10.1038/SJ.CDD.4401987
Meiyu Wang, Jia Lu, Jiajun Li, Huixin Qi, Yedong Wang, Hongjian Zhang, Steviol glucuronidation and its potential interaction with UDP-glucuronosyltransferase 2B7 substrates. Food and Chemical Toxicology. ,vol. 64, pp. 135- 143 ,(2014) , 10.1016/J.FCT.2013.11.028
Murat Kara, Onder Yumrutas, Onder Ozcan, Ozgur Ilhan Celik, Esra Bozgeyik, Ibrahim Bozgeyik, Sener Tasdemir, Differential expressions of cancer-associated genes and their regulatory miRNAs in colorectal carcinoma. Gene. ,vol. 567, pp. 81- 86 ,(2015) , 10.1016/J.GENE.2015.04.065
Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel, Most mammalian mRNAs are conserved targets of microRNAs Genome Research. ,vol. 19, pp. 92- 105 ,(2008) , 10.1101/GR.082701.108
S Hibino, Y Saito, T Muramatsu, A Otani, Y Kasai, M Kimura, H Saito, Inhibitors of enhancer of zeste homolog 2 (EZH2) activate tumor-suppressor microRNAs in human cancer cells. Oncogenesis. ,vol. 3, ,(2014) , 10.1038/ONCSIS.2014.17