Parathyroid carcinoma, atypical parathyroid adenoma, or parathyromatosis?

摘要: BACKGROUND. Parathyroid carcinoma, atypical parathyroid adenoma, and parathyromatosis can be differentiated relatively easily from typical adenomas, but distinguishing them each other is more difficult. METHODS. A retrospective study of 28 consecutive patients with 7 13 who were treated at the University California San Francisco Medical Center between 1966 2005 was performed. Patient demographics clinical characteristics, indication for surgery, intraoperative findings, histopathologic disease recurrence or persistence, site invasion/metastases, survival compared in 3 groups. RESULTS. Parathyroid carcinoma (19 patients) adenoma (4 significantly common men, whereas women (10 (P = .02). A palpable neck mass hoarseness almost exclusively present carcinoma. Prior to first found have higher blood calcium levels (≥14 mg/dL 16 26 [62%]), only 1 6 (17%) no profound hypercalcemia < .01). Intraoperatively, presented single lesions, had multiple small lesions. Histopathologic findings well defined some overlapped tumors studied. CONCLUSIONS. Patients often differ those time presentation because as invasive tumors. However, times it difficult distinguish these conditions both clinically by final histologic examination. Cancer 2007. © 2007 American Society.