Mechanical and Structural Contribution of Non-Fibrillar Matrix in Uniaxial Tension: A Collagen-Agarose Co-Gel Model

摘要: The mechanical role of non-fibrillar matrix and the nature its interaction with collagen network in soft tissues remain poorly understood, part because lack a simple experimental model system to quantify these interactions. This study’s objective was examine structural properties collagen-agarose co-gels, utilized as simplified system, understand better relationships between matrix. We hypothesized that presence agarose would have pronounced effect on microstructural reorganization behavior. Samples fabricated from gel solutions containing 1.0 mg/mL 0, 0.125, or 0.25% w/v were evaluated via scanning electron microscopy, incremental tensile stress-relaxation tests, polarized light imaging. While incorporation did not dramatically alter morphology, led concentration-dependent changes properties. Specifically, resistance co-gels volume change corresponded differences fiber reorientation elastic/viscoelastic mechanics. Results demonstrate strong tissue offer insight into behavior varying Poisson’s ratio kinematics. also suggest material may significant effects artificial native even tension, which is generally assumed be dominated.