The Role of Epigenomics in the Study of Cancer Biomarkers and in the Development of Diagnostic Tools.

摘要: Epigenetics plays a key role in cancer development. Genetics alone cannot explain sporadic and development individuals with no family history or weak of cancer. provides mechanism to the such situations. Alterations epigenetic profiling may provide important insights into etiology natural Because several changes occur before histopathological changes, they can serve as biomarkers for diagnosis risk assessment. Many cancers remain asymptomatic until relatively late stages; managing disease, efforts should be focused on early detection, accurate prediction disease progression, frequent monitoring. This chapter describes are expressed during their potential use prognosis. Based epigenomic information, have been identified that diagnostic tools; some also useful identifying who will respond therapy survive longer. The importance analytical clinical validation is discussed, along challenges opportunities this field.