作者: Nitza Zilberman , Rusinek Inbar , Eli Schwartz , Uriel Katz
DOI: 10.1111/J.1708-8305.2006.00017.X
关键词:
摘要: In February 2005, the number of cases acute diarrhea in Malabo, island capital Equatorial Guinea (Figure 1) started to rise. The unusual, and severe presentation together with fast dehydration knowledge recent presence diarrheic disease caused by Vibrio cholerae country's mainland prompted health authorities consider this pathogen. Stool cultures serotypification confirmed V. cholera affected individuals. Cholera is a gram‐negative rod , which acquired oral–fecal contamination like most pathogens.1 If pathogen able pass barrier gastric acidity due high inoculum (over 108 bacteria)2 or reduction (malnutrition, use antacids, atrophic gastritis, etc.), it adheres colonizes intestinal mucosa. attaches mucosa means toxin (A subunit), action enzymatic B subunit toxin, acts on epithelial cells leads an intracellular elevation cyclic adenosine monophosphate, causing secretion chloride blocking absorption sodium among other disturbances.1 This may result massive watery that can lead death course few hours if person not treated. Fluid electrolyte repletion are paramount treatment.1,2 Antibiotics shorten disease, additionally reducing days patients shedding pathogens.2,3 At request government Guinea, team two physicians nurses from Chaim Sheba Medical Center Israel was sent Malabo help care patients, assess situation, recommend measures intended stop spreading … Corresponding Author: Eli Schwartz, MD, DTMH, for Geographic Medicine Department C, Center, Tel HaShomer, 52621 Israel.