Pharmacokinetics of percutaneous absorption with concurrent metabolism

作者: Richard H. Guy , Jonathan Hadgraft

DOI: 10.1016/0378-5173(84)90216-3

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摘要: Abstract A pharmacokinetic model for percutaneous absorption has been formulated which allows calculation of the drug disposition in skin, plasma and urine. Allowance is also made metabolic processes within skin. The influence metabolism on concentrations parent molecule metabolite discussed.

参考文章(3)
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Jonathan Hadgraft, Theoretical aspects of metabolism in the epidermis International Journal of Pharmaceutics. ,vol. 4, pp. 229- 239 ,(1980) , 10.1016/0378-5173(80)90138-6
Ronald C. Wester, Patrick K. Noonan, Relevance of animal models for percutaneous absorption International Journal of Pharmaceutics. ,vol. 7, pp. 99- 110 ,(1980) , 10.1016/0378-5173(80)90054-X