In vivo evaluation of acyclovir prodrug penetration and metabolism through rat skin using a diffusion/bioconversion model.
作者： Hiroto Bando , Mikiko Sahashi , Fumiyoshi Yamashita , Yoshinobu Takakura , Mitsuru Hashida
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摘要: Purpose. In order to evaluate the in vivo penetration of prodrugs which undergo metabolism skin, we analyzed thein profiles acyclovir based on a two-layer skin diffusion model consideration metabolic process.
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