The physicochemical properties, plasma enzymatic hydrolysis, and nasal absorption of acyclovir and its 2'-ester prodrugs
作者： Zezhi Shao , Gee‐Bae Park , Ramesh Krishnamoorthy , Ashim K. Mitra
关键词: Chromatography 、 Enzymatic hydrolysis 、 Nasal Absorption 、 Solubility 、 Prodrug 、 Lipophilicity 、 Nasal administration 、 Organic chemistry 、 Hydrolysis 、 Valerate 、 Chemistry
摘要: A series of 2′-(O-acyl) derivatives of 9-(2-hydoxyethoxymethyl)guanine (acyclovir) was synthesized by acid anhydride esterification. Aqueous solubilities in isotonic phosphate buffer (…
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