Membrane lipidomics for the discovery of new antiparasitic drug targets.
作者： Eric Maréchal , Mickaël Riou , Dominique Kerboeuf , Frédéric Beugnet , Pierre Chaminade
关键词:
摘要: Advances in lipid separation methods and mass spectrometry technologies allow the fine characterization of lipidome parasites, ranging from unicellular protists to worms, which cause threatening infections vertebrates, including humans. Specific structures or metabolic pathways can inspire development novel antiparasitic drugs. Changes balance membranes parasites also provide clues on dynamics drugs some mechanisms drug resistance. This review highlights recent trends parasite lipidomics, combined with functional analyses, for discovery targets
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