Nuclear mRNA Surveillance Mechanisms: Function and Links to Human Disease

摘要: Abstract Production of export-competent mRNAs involves transcription and a series dynamic processing modification events pre-messenger RNAs in the nucleus. Mutations genes encoding mRNP machinery complexities involved biogenesis lead to formation aberrant messages. These faulty transcripts are promptly eliminated by nuclear RNA exosome its cofactors safeguard cells organisms from genetic catastrophe. components core tissue-specific dysfunction exosomal activities, which linked diverse human diseases disorders. In this article, we examine structure function both yeast complex cofactors, discuss nature various altered amino acid residues implicated these with speculative mechanisms mutation-induced disorders project frontier prospective avenues future research field.