Circulating fibroblast growth factor-like autoantibodies in two patients with multiple endocrine neoplasia type 1 and prolactinoma.

摘要: Basic fibroblast growth factor (bFGF) is a potent endothelial cell mitogen found in variety of normal and tumor tissues. bFGF lacks classical amino-terminal signal sequence not readily detectable plasma from subjects. In earlier studies we showed increased bFGF-like mitogenic activity for parathyroid-derived cells (increased) immunoreactivity (0.24-1.28 ng/mL) subjects with multiple endocrine neoplasia type 1 (MEN-1). the present study examined proliferative MEN-1 plasmas (applied to protein-A columns) calf pulmonary artery cells. Protein-A-eluted prolactinoma exceeded nonprolactinoma three eight untreated or recurrent prolactinoma. active fractions had several properties an immunoglobulin G, including affinity antihuman G (IgG) agarose...